Killed oral cholera vaccines: history, development and implementation challenges

Protection against cholera from killed whole-cell oral cholera vaccines: a systematic review and meta-analysis

BACKGROUND Killed whole-cell oral cholera vaccines (kOCVs) are becoming a standard cholera control and prevention tool. However, vaccine efficacy and direct effectiveness estimates have varied, with differences in study design, location, follow-up duration, and vaccine composition posing challenges for public health decision making. We did a systematic review and meta-analysis to generate avera...

Oral vaccines against cholera.

The current seventh pandemic of cholera, caused by serogroup O1, El Tor biotype, has now involved almost the entire developing world. The ongoing dynamic epidemiology of cholera, involving evolution of new strains, prolonged and more frequent epidemics, increased antimicrobial resistance, and awareness of the role of climate change upon the global burden has returned cholera to the forefront of...

The Compositions and Protective Efficacies of the Oral Killed 2 Cholera Vaccines : A Critical Analysis

Manuscript Text File 1 The Compositions and Protective Efficacies of the Oral Killed 2 Cholera Vaccines: A Critical Analysis 3 Shahjahan Kabir 4 Academic Research and Information Management, 754 37 Uppsala, Sweden 5 6 Address correspondence to Shahjahan Kabir, [email protected] 7 ABSTRACT 8 Two cholera vaccines, sold as Shanchol and Dukoral, are currently available. This review 9 presents a cr...

Development of new African horsesickness cell culture killed vaccines

Controlling Endemic Cholera with Oral Vaccines

BACKGROUND Although advances in rehydration therapy have made cholera a treatable disease with low case-fatality in settings with appropriate medical care, cholera continues to impose considerable mortality in the world's most impoverished populations. Internationally licensed, killed whole-cell based oral cholera vaccines (OCVs) have been available for over a decade, but have not been used for...